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Home - Products - Chromatin/Epigenetic - Bromodomain - AZD5153 6-Hydroxy-2-naphthoic acid

AZD5153 6-Hydroxy-2-naphthoic acid

CAS No. 1869912-40-2

AZD5153 6-Hydroxy-2-naphthoic acid ( AZD 5153 6-Hydroxy-2-naphthoic acid;AZD-5153 6-Hydroxy-2-naphthoic acid )

Catalog No. M12891 CAS No. 1869912-40-2

A potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZD5153 6-Hydroxy-2-naphthoic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.
  • Description
    A potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM; simultaneously binds to two bromodomains in BRD4; exhibits antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.
  • Synonyms
    AZD 5153 6-Hydroxy-2-naphthoic acid;AZD-5153 6-Hydroxy-2-naphthoic acid
  • Pathway
    Chromatin/Epigenetic
  • Target
    Bromodomain
  • Recptor
    BD1-BRD4;FL-BRD4
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1869912-40-2
  • Formula Weight
    667.75
  • Molecular Formula
    C36H41N7O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 34 mg/mL
  • SMILES
    CC1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C.C1=CC2=C(C=CC(=C2)O)C=C1C(=O)O
  • Chemical Name
    2-Naphthalenecarboxylic acid, 6-hydroxy-, compd. with (3R)-4-[2-[4-[1-(3-methoxy-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy]ethyl]-1,3-dimethyl-2-piperazinone (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bradbury RH, et al. J Med Chem. 2016 Sep 8;59(17):7801-17.
2. Rhyasen GW, et al. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.
3. Collins TA, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Jun;6(6):357-364.
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